Staff Profile

Nathaniel Mercaldo, PhD

Co-chair, Statistics
Instructor in Radiology/Statistics, Harvard Medical School
Statistician in the Department of Radiology at Massachusetts General Hospital
Dr. Mercaldo received a BS in Applied Mathematics and Microbiology from the University of Idaho, an MS in Biostatistics from the University of Washington, and a Ph.D. in Biostatistics from Vanderbilt University. He is a Statistician in the Department of Radiology at Massachusetts General Hospital, and an Instructor of Radiology and Statistics at Harvard Medical School. His research interests include: the development of flexible and efficient epidemiological study designs for longitudinal binary data, the development of software for the analysis of marginalized regression models, and the analysis of high-dimensional data with applications in neurology and radiology.

Selected Publications

Sikosek, Tobias; Horos, Rastislav; Trudzinski, Franziska; Jehn, Julia; Frank, Maurice; Rajakumar, Timothy; Klotz, Laura V; Mercaldo, Nathaniel; Kahraman, Mustafa; Heuvelman, Marco; Taha, Yasser; Gerwing, Jennifer; Skottke, Jasmin; Daniel-Moreno, Alberto; Sanchez-Delgado, Marta; Bender, Sophie; Rudolf, Christina; Hinkfoth, Franziska; Tikk, Kaja; Schenz, Judith; Weigand, Markus A; Feindt, Peter; Schumann, Christian; Christopoulos, Petros; Winter, Hauke; Kreuter, Michael; Schneider, Marc A; Muley, Thomas; Walterspacher, Stephan; Schuler, Martin; Darwiche, Kaid; Taube, Christian; Hegedus, Balazs; Rabe, Klaus F; Rieger-Christ, Kimberly; Jacobsen, Francine L; Aigner, Clemens; Reck, Martin; Bankier, Alexander A; Sharma, Amita; Steinkraus, Bruno R

Early Detection of Lung Cancer using small RNAs Journal Article

In: J Thorac Oncol, 2023, ISSN: 1556-1380.

Abstract | Links | BibTeX

Kocak, Burak; Baessler, Bettina; Bakas, Spyridon; Cuocolo, Renato; Fedorov, Andrey; Maier-Hein, Lena; Mercaldo, Nathaniel; Müller, Henning; Orlhac, Fanny; Santos, Daniel Pinto Dos; Stanzione, Arnaldo; Ugga, Lorenzo; Zwanenburg, Alex

CheckList for EvaluAtion of Radiomics research (CLEAR): a step-by-step reporting guideline for authors and reviewers endorsed by ESR and EuSoMII Journal Article

In: Insights Imaging, vol. 14, no. 1, pp. 75, 2023, ISSN: 1869-4101.

Abstract | Links | BibTeX

Yoon, Byung C; Pomerantz, Stuart R; Mercaldo, Nathaniel D; Goyal, Swati; L'Italien, Eric M; Lev, Michael H; Buch, Karen A; Buchbinder, Bradley R; Chen, John W; Conklin, John; Gupta, Rajiv; Hunter, George J; Kamalian, Shahmir C; Kelly, Hillary R; Rapalino, Otto; Rincon, Sandra P; Romero, Javier M; He, Julian; Schaefer, Pamela W; Do, Synho; González, Ramon Gilberto

Incorporating algorithmic uncertainty into a clinical machine deep learning algorithm for urgent head CTs Journal Article

In: PLoS One, vol. 18, no. 3, pp. e0281900, 2023, ISSN: 1932-6203.

Abstract | Links | BibTeX

DiGennaro, Catherine; Vahdat, Vahab; Jalali, Mohammad; Toumi, Asmae; Watson, Tina; Gazelle, G Scott; Mercaldo, Nathaniel; Lubitz, Carrie C

Assessing Bias and Limitations of Clinical Validation Studies of Molecular Diagnostic Tests for Indeterminate Thyroid Nodules: Systematic Review and Meta-Analysis Journal Article

In: Thyroid, vol. 32, iss. 10, pp. 1144-1157, 2022, ISSN: 1557-9077.

Abstract | Links | BibTeX

Rajakumar, Timothy; Horos, Rastislav; Kittner, Paul; Kahraman, Mustafa; Sikosek, Tobias; Hinkfoth, Franziska; Tikk, Kaja; Mercaldo, Nathaniel D; Stenzinger, Albrecht; Rabe, Klaus F; Reck, Martin; Thomas, Michael; Christopoulos, Petros; Steinkraus, Bruno R

Brief Report: A Blood-Based MicroRNA Complementary Diagnostic Predicts Immunotherapy Efficacy in Advanced-Stage NSCLC With High Programmed Death-Ligand 1 Expression Journal Article

In: JTO Clin Res Rep, vol. 3, no. 8, pp. 100369, 2022, ISSN: 2666-3643.

Abstract | Links | BibTeX

Rajakumar, Timothy; Horos, Rastislav; Jehn, Julia; Schenz, Judith; Muley, Thomas; Pelea, Oana; Hofmann, Sarah; Kittner, Paul; Kahraman, Mustafa; Heuvelman, Marco; Sikosek, Tobias; Feufel, Jennifer; Skottke, Jasmin; Nötzel, Dennis; Hinkfoth, Franziska; Tikk, Kaja; Daniel-Moreno, Alberto; Ceiler, Jessika; Mercaldo, Nathaniel; Uhle, Florian; Uhle, Sandra; Weigand, Markus A; Elshiaty, Mariam; Lusky, Fabienne; Schindler, Hannah; Ferry, Quentin; Sauka-Spengler, Tatjana; Wu, Qianxin; Rabe, Klaus F; Reck, Martin; Thomas, Michael; Christopoulos, Petros; Steinkraus, Bruno R

A blood-based miRNA signature with prognostic value for overall survival in advanced stage non-small cell lung cancer treated with immunotherapy Journal Article

In: NPJ Precis Oncol, vol. 6, no. 1, pp. 19, 2022, ISSN: 2397-768X.

Abstract | Links | BibTeX

Weinstein, Debra F; Choi, Jin; Mercaldo, Nathaniel; Stump, Natalie; Paras, Molly L; Berube, Rhodes A; Hur, Chin

Is Resident-Driven Inpatient Care More Expensive? Challenging a Long-Held Assumption. Journal Article

In: Academic medicine : journal of the Association of American Medical Colleges, vol. 96, iss. 8, no. 1205-1212, 2021, ISSN: 1938-808X.

Abstract | Links | BibTeX

Frenk, Nathan E; Bochnakova, Teodora; Ganguli, Suvranu; Mercaldo, Nathaniel; Allegretti, Andrew S; Pratt, Daniel S; Yamada, Kei

Small-diameter TIPS combined with splenic artery embolization in the management of refractory ascites in cirrhotic patients. Journal Article

In: Diagnostic and interventional radiology (Ankara, Turkey), vol. 27, no. 2, pp. 232-237, 2021, ISSN: 1305-3612, ().

Abstract | Links | BibTeX

Duan, Yu; Xie, Xiaoyan; Li, Qian; Mercaldo, Nathaniel; Samir, Anthony E; Kuang, Ming; Lin, Manxia

Differentiation of regenerative nodule, dysplastic nodule, and small hepatocellular carcinoma in cirrhotic patients: a contrast-enhanced ultrasound-based multivariable model analysis. Journal Article

In: European radiology, vol. 30, pp. 4741–4751, 2020, ISSN: 1432-1084, ().

Abstract | Links | BibTeX

Zhou, Iris Y; Jordan, Veronica Clavijo; Rotile, Nicholas J; Akam, Eman; Krishnan, Smitha; Arora, Gunisha; Krishnan, Hema; Slattery, Hannah; Warner, Noah; Mercaldo, Nathaniel; Farrar, Christian T; Wellen, Jeremy; Martinez, Robert; Schlerman, Franklin; Tanabe, Kenneth K; Fuchs, Bryan C; Caravan, Peter

Advanced MRI of Liver Fibrosis and Treatment Response in a Rat Model of Nonalcoholic Steatohepatitis. Journal Article

In: Radiology, vol. 296, pp. 67–75, 2020, ISSN: 1527-1315, ().

Abstract | Links | BibTeX