Dr. Pamela McMahon and ITA research staff collaborated with other mathematical modelers as part of the National Cancer Institute’s Cancer Intervention and Surveillance Modeling Network to the special issue of Risk Analysis: The Impact of the Reduction in Tobacco Smoking on U.S. Lung Cancer Mortality (1975-2000): Collective Results from the Cancer Intervention and Surveillance Modeling Network. This monograph quantifies the impact of changes in smoking behaviors on lung cancer mortality based on detailed reconstructions of cigarette smoking histories for people born from 1890 to 1970. The issue details how this modeling was accomplished as well as describing how many lung cancer deaths have been averted due to declines in smoking and how many more deaths could have been averted had tobacco control efforts been perfect in eradicating cigarette smoking just after the first Surgeon Generals’ report.