Barrett’s esophagus - the construction and continued refinement of this disease model has allowed analyses that have attempted to determine the optimal management strategy for those patients with this pre-malignant condition which is a precursor to esophageal cancer. Specific analyses have addressed the cost-effectiveness of endoscopic surveillance, photodynamic therapy, as well aspirin for chemoprevention. Future areas of research include patient preferences in Barrett’s high grade dysplasia which is currently an area of much controversy.